GENE THERAPY (VIRAL AND NON-VIRAL VECTORS) Essay

GENE THERAPY (VIRAL AND NON-VIRAL VECTORS) - Essay Example HVS (Harpes Simplex Virus Vector) happens to be the most complex as well as the largest among all viruses under development for gene therapy with one of its features of importance being that it has a capacity that is able to carry he fragments for foreign DNA (Mohammed, Al-Dosari1, & Xiang 2009). Hybrid vectors- in demand for better vectors, most researchers are trying to combine significant features of distinct viruses in hybrid vectors. Among the fascinating hybrids brings together the site specific integration machine for wild type AAV together with the nuclear targeting as well as efficient internalization properties of adenovirus (Clare, Anja, & Mark 2003). There seems to be a bright future for vectors given that vectors development within the past several years has encouraging results. Less immunogenic vectors have been deleted through creation of new gene production systems that are efficient. The haematopietic cells’ ex vivo transduction has been improved in its efficiency. The in vivo trans-gene expression has been improved in its efficiency and specificity by means of tissue specific optimization as well as inducible promoters. There has been expansion of vector tropisms repertoire as well as pre-existing immune responses evasion by developing alternative viral serotypes (Clare, Anja, & Mark 2003). Several applications of gene therapy look promising in clinical early phase trial for instance haemophilia B treatment by use of rAAV, vascular and coronary artery disease treatment by use of viral vectors and certain kinds of cancer treatment by use of â€Å"conditionally replicating ecolytic viruses† (Kenneth & Teni 2003). Viral-vectors- Typically, viral vectors do consist of viral particles that have nucleic acid with a capseid protein covering it at least and mostly further by the structure of an envelope. In general, one or a number

Customer Relationship Management Program Case Study

Customer Relationship Management Program - Case Study Example Both companies before merger had well-developed Customer Relationship Management program according to their respective visions and the employees have trained accordingly (Dyche & Wesley, 185). After the merger, the focus was on coming up with a Customer Relationship Management system to satisfy the needs and demands of the employees and customers of both companies, while communicating the new brand philosophy and vision. In this regard, the company had to face and overcome different challenges and issues. The major issue was of establishing consensus on the values and vision of the Customer Relationship Management program. Implementation of the new Customer Relationship Management program demands extensive attention from the top management. In order to ensure efficient and effective implementation of the Customer Relationship Management system, the top management of the organizations should come up with appropriate plans and strategies. Most important step in this regard is to make sure that overall organization is ready for the implementation of a new Customer Relationship Management program. The organization should start with scanning the internal and external environment in order to identify any hurdle or resistance. Apart from this, it is essential to train and educate the employees about the new Customer Relationship Management system so that an understanding of CRM is developed. Implementation of the Customer Relationship Management program requires well-thought change management strategies so that the organization is able to minimize resistance and at the same time is able to take help from the supportive factors. In order to ensure successful implementation of the Customer Relationship Management program, it is important to identify important customers with whom the organization want to interact.